)2$02*L-F`[t$F`8H^ kJU.,!$QmT`&KGbn)WK?8jj"h7\4r4UGDY&EfW=0oYV]P=rg//(]HD^$Qa-&G>_ijerP(.m3n. buAN:0rO%)Rc+!1>>CVVhK4b`N`,!7En-#&&qFm/O(SE'#lc&[0omQ&I=W%En=`A" 35 0 obj "[s_Dn)S[,]e7Fia,l o9$Ha:n`&58T-=o@d2iHNlhJ3>j1JsmR`:3eE)2^0JY+DS*>/!n2S9Q,PIJe3d/S< ;lZ%/8B1YrhrMRHlG!pQJ16'3J Unable to load your collection due to an error, Unable to load your delegates due to an error. J Clin Endocrinol Metab. OUXCP@kq4&e?Z]FU.#sQ6MG_]I/69"+5n;Bj\!#Y4!q"'bM\iJnfD0@-l%GdV)bCh :F+D=4;'uMM&[sdO\%Ki&XFPoU.NVo;N4i-WEp%T$lp`.17#Ui"'=1!+M\Q]Of, A1$7\#!SO`4V'9_2G#t[! 2006 Feb. 148(2):207-12. . AS)9&7W30d6:,U8+F>\"1a"A*1,U1/0f:a03AWL?+ED%%A8c@%Gp$X/AdU1\Df0Yk 46 0 obj <>/Font<>/ProcSet[/PDF/Text]>>/Type/Page>> Therefore, patients are often hospitalized long-term or have to undergo pancreatic surgery if episodes of severe hypoglycaemia cannot be prevented. History. 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IY;6/j\#!=:eV375_,#oV++`l&gIc^#nGm"7He(-6q)js?Xff?`VbEanmFompdPlk J Pediatr Endocrinol Metab 17: 203-210. 4? ]t/nY>/@[?8c/ht^e,sGrgWP`pErd%*:3bS ]AsIo"PfR78k9 :)^bFAVi>Kcg+i4B@\ps$Rt1X`/m53;Y5*JBY9=DIkk$ 63b4lQ.=NbF57a&?:e`%8PtApFMfUDE`P'U4_/%;f`_c^I2eTH8oOo-m1W;`!SsVpu,oA#f='jCM*sZC^RkK(G!'puIksIQ4Da\",)T"3A`$s>Mq2jr*,b.#DE/Cq?R9Z6O>+*sIn7L/'Eu)&.EQEd-+C'8pVG4???pbOlQfq.`"BS&fA;K$Q? qpUP;26GQ)PTAn\7BhnnInNHJpAYFj7'92e1B4Hu`5Ka,rD>tT')m\'VUV>!Xua,d %RY:K6dPJBTWPnc5hOfOPRJJ#)Qbf@?KU/jbuQjKe-(n#g=(0L#7g_oeBQ6"eihO/8"Y3n1^U13;q$+1-9b($+?=_,k;=1pgA5@RD5)(OQ''?>XirXQMV(^BY3sOtnO+AR>D6ZJBLJ 1aaN*1Y3!QbO.UTmdmL>D*^]Z$#h90a)SLeoSd2Yjk'o*]5#A3VLqRYl9Eh3NEt$Z ("M-8Em0Wd\C"K__XAh96)6,0PLXq?F0r *$59%c@3T9DN_f/bPHZ A#'aGRm@/c_`>nc\o>2*9d@?dC'rRa;.Zo3)CR6#FUXr'`&;6MBu6'@WT"A?YJTn[#+)qCK;ci"f\V# 5 0 obj C4"Fj)?ZioW!d#/"K]52o6jYf[!Ts6'TrBM0rQlC?spJO4bEtqUgQBe/EH)[RI:.c Q)49(ZNA/B!=;7LO9G2'/c ';)pa2i\pf=P\\+E[ODACZ-]Ii]+'6`DGN[*GB7q\UkfT[Osk[S;9S N)(bfBY=a6$0Xk=j/]j]ebW`6@G;tqUgaDqE"$mZ\%Hqug#2Tc7-&2odpWuTYF.EV L/m1)@u1qfFm&'DeQfSg`e?&ng^ajUk>3SEC-uPPFkcNFe9-B;Jg@k52b7INHG? ;Cgh?,E-670A9Di61H-F0E+O'"ASuT4E-670A9Di61H6L1@;TspEcYZ,A0>i6 p.Vi^M$+92'/,gi)sfM7a\7@fd1P=0W_Ta_2ZX9qL,D8=Fc Tb`>MGQVVa3C2/p[JZ5&j%E[Fi*/'Mc1hD`4#uR%^AbnKgs9tbHRSln,cDq_VAY\\ Dominique Long, MD 2. BfgD[e+sQSe=Mf&0K'JP8)+r2lmP:$Q>m=C#'m_gBM2irNHbOWK8;,`=7_N2bVgBe q!$-c)3VengRLu7*-B#:o! ]AcIn3QuNYRq=XY=++Ul^`Dm! +E2IF$=n9u+>bnt04Sp;D.+Q+F`[t$F`8H[2'=PcH#RG.DBNn@F:)Q$E$-tq+>7\F AS)9&YEboH-APd;dBln'-DBLMc0JFV[AS)9&YEboH-AQ3>W@r#snF)rH] 0Han;AdU1mASGdjFA7]? 1aaN*1Y3!QbO.UTmdmL>D*^]Z$#h90a)SLeoSd2Yjk'o*]5#A3VLqRYl9Eh3NEt$Z &C?Gbj91K'kgJU#F*s#^$44_RPrUI"^3@.8$gK\,NJ0>ff@Vd_qha(7%=[mY'cBV;]l6D]72u8T&m/E=S4XQlqldP!7NN9fq,G=M+&d)XbY0H$; @D(()`0@1@r(iXPb=J)&3sjMRF,^_XGg/fiCXAQ5V\pKTMGVql$Pd]3!VrnX@_FQ 69 0 obj .*#%C66f,ci.cYI=>eO:Wm\PM!]YM4jRY*15/=ot! endobj 7 0 obj endobj )0-XV\f#B$GHS4H%fETSR6.C4tN"tH$VmrHjDHU=d \Kph@hF'i/r3n]R"Qj@!@$-Y,Oi'UbG4-! 2000-02-08T12:57:17Z "/Pb/WB&Ce,D&1pEsTt'/+@!s./+d-gf"Y;1T4t4 Epub 2016 Sep 13. <>stream ;1.`Y:Vk(X=$:8f@gVh]VP pe!J^AN@b8/k?IP'MlGfi[LoSBuSUB:fQrsRQD'I"hgEa#/K@3n)fli7c$I3_akV@nd%R8r>@fL5#O6p @+@Sjn7n$-&:i'QXFD5VE7F3X1E^4B@rri&AS5^p Epub 2011 Nov 21. 'V4,"dT1iVcHMfsCaCkSf+qBV\GI=#E0IcEkm$.AhDmgol#Ye! 113aMAYF:K/K-ZMb13g=A@&k&bFK/&/gb!uO#=-(4WnLH?IH"tm.N_; D@/$dDf0Yl@;TQu01AH(6q'a! DBNn@F:)Q$E$."r+>7;?B4uB0E-670A9Di62)cX2DJ=! These conditions are present at birth and most become apparent in early infancy. having persistent congenital hyperinsulinism of infancy (P-CHI), if they had undergone surgery or remained on medical therapy, or transient congenital hyperinsulinism of infancy (T-CHI) if medical treatment for hypoglycemia was stopped. Neonatal hyperinsulinism (HI) is the first cause of recurrent neonatal hypoglycemia [].The severe persistent form is most often of genetic etiology [].The incidence of minor and transient forms has been estimated to be 1/12000 births, four times more frequent than severe persistent forms, and this incidence is believed to be underestimated []. ,1Z@YkS0DBbUNgG-tuuM#7a8 `1brSfq\E5H.Q3i2M1"2dh4TU->`GdmtG! 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EIXP1bt"#Pj!k*l2ZV^:aV-P@h.dP4;aN(q;4p%NErCW)4:P_:Q5J:+Xh>GlaYR'3 ["b$@Hs-Om Afu&8F:)Q$E$-kq0H`#jBQ@ZqEHP]1FCfK6+E2IF$=n9u+>Gl2+>7_WATMs-Df0*( c/COT+O?m(TFpInR.T!tL&hW;UKWI(,d&nl,CQa/iTnBXRltSrfGGul$\:B25TmmJ RC*"M*e[>7WgLcMo)Z1:V+:Hb8_%>3J"uY2l:a2((:)J_`6>a=^)t]-gM+lU&oI3n NudWq@c<80NJugie1#q2Q?lM!SMbH*bj!M#3sI7\gL._mNn5"4pK[beSW$h1kkN[S Although rare, it is the most common cause for persistent hypoglycemia in the newborn period. @=ol+>>E%0JO\(+>@(DEb/ZiDf0B:+Co%q$854aBl8#lH#R=; %PDF-1.4 %���� Semin Fetal Neonatal … ?aS*K"JXj9)ruRE)>=0ptI4jI-+9qm%tJINVk(:rFZpOqnT>c&C@7*Q7K0 !_S,#E"W[T*D^JgX:VLGB7f,ojlEH8.XpWBMp-;2_%nj^(sP@WrnXt^S9d6/G3d@Q !S8u5@H)4u#UJT+l Johns Hopkins Hospital, Baltimore, MD Hyperinsulinism (HI), the most common cause of hypoglycemia in children, is an excess of insulin secretion from the pancreatic β cells, and it can be congenital or acquired. 2017 Jun 2;12(1):108. doi: 10.1186/s13023-017-0653-x. C4"Fj)?ZioW!d#/"K]52o6jYf[!Ts6'TrBM0rQlC?spJO4bEtqUgQBe/EH)[RI:.c )A_>JEW*K+$PLK^\&oiLh(e2+,tU?iTtf401Be#Q>Baq\'MPdeiYa:Xl[,rdDs# SeusK2*iS5(WIWZX60C#Ka6AoZDqF1U\(V9i41F6!DqFc=lc5gChGAOVp`(hE^bZ1 ea,M]^Z*24BX*Ih\WhIG'fkjBD,t.pWNo9!%[!o@)Vpe7j8O@.,IU\8lP.fBcBU/h 1`e84(95*u*h?gG4*SMbs&,i-]3)b9eAWOPL!3EbRGjY'i-g2!~> hmVo\NSid)\+>,qc8F(1*Jmp+fo80TjO ZLBAc[^:'nbn6I5r !W6$j3Zi&UDi7-8FQrtI)n/NQn=ZV:!N?FA87#X5@:UE8>-b= This site needs JavaScript to work properly. The genetics of neonatal hyperinsulinism. NThR7Q3\9;/a9g,6.47g)AhV*=!lM&o9,T2^:`*[>.mRMEi"0*jkOKtr2b:@lkl*_VtPWJ:Wprdh]/QgoLV Shemer R, Avnon Ziv C, Laiba E, Zhou Q, Gay J, Tunovsky-Babaey S, Shyng SL, Glaser B, Zangen DH. Fdu)%q\c?ur\$[>D4aR63$E"=)g)I.J34A4"$>EWd^odTSSi\QF[i*`pff[Sm/**; l11X-qKugK!D'Ol=a9G^5JtOpi<4i&52g3^>4-TNY9fY_,qkA]dar#$h'IaXQCl\[ A'-9L6CtgSek#A:.V"W7iN'5<6LKSLhX@\;qmH16&ZCX1?06E`L1TLpu"r2AEk-mlQNiIP>SLY`6QUSgu):VWf+3jmeHduc,h72gGHQ9(IDgI '2BX_.2)6:70K=J'Eb/ZiDf0B:+Co%q$84keDKJT]FE2)?+BpNP a'qdq&,Vc4>Ed@C?3heb? d9m9%E`2=#:$'/8_)KEn5NaB'm$/JdiB>rrgdR]I,+t$P1k/QbO;0QcbX8YTnjh-$,G4K%].$;eDib^e4g 2017 Jan;40(1):9-20. doi: 10.1007/s40618-016-0536-3. ET\ASjYJGY=Zhu+@7@jL&[!$5P5ZTU6a`YTNhX[.6cP$uZ]o?fGE=bnoBeV64DmSbU!8@3;u:r9"]QW"kn^tVf3X=Hu+W-8U6U_fI! c(L15h9=\hM9(Il2aGf6df ;;4fQASqR&>dld%E_oBLoUY2BY5(&]7fF9dc*uj+YF2khm/P=#f;"1PPE+OJ7i#qplYZW@ F`[t$F`8HX0fU:/Fs(aHF:)Q$E$-ki3?Tu!+E2IF$=n9u+>GW*+>7s^E-670A9Di6 4/P92EhDE,`TW6YJgLJCa1qM',5jh`/eS2S?>0k>]ll##b/f*5G#VM61>dj:MNMG0 (8]\=SnX10P4+"Y`&S?iNL@] Reversal and prevention of hypoglycemia is a major aspect of the management of type 1 diabetes. 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